The pathogenesis of OCD is still unclear, and studies have shown that the onset of OCD is related to abnormalities in the function of dopamine and 5-hydroxytryptamine in the brain. The drugs used clinically to treat OCD are all antidepressants, which mainly target the regulation of the 5-hydroxytryptamine system in the brain. Currently, the following drugs are recognized as effective: tricyclic antidepressants such as clomipramine; selective 5-hydroxytryptamine reuptake inhibitors such as fluvoxamine, sertraline and paroxetine; 5-hydroxytryptamine and norepinephrine reuptake inhibitors such as venlafaxine hydrochloride; norepinephrine and specific 5-hydroxytryptaminergic antidepressants such as mirtazapine. Clomipramine has long been the first line of treatment for OCD. Due to the large side effects of clomipramine, it is now used less frequently. SSRIs have become the mainstream treatment for OCD, and their effects are basically comparable to clomipramine, and they are convenient, safe and have fewer side effects. The size of the dose to be taken depends on the patient’s tolerance level and the safety of the drug, etc. Generally speaking, the target dose of medication for OCD is higher than that for depression. For patients with severe anxiety, benzodiazepines can be combined with OCD; for refractory OCD, small doses of atypical antipsychotics such as quetiapine and aripiprazole can be combined to improve the efficacy of treatment. Patients in the process of taking medication need to pay attention to the following aspects: 1, the treatment of obsessive-compulsive drug side effects Many patients and their families may have certain misconceptions about taking medication, worried that after taking medication may lead to unresponsiveness, mental retardation, may also cause permanent brain or other organ damage, and even affect the future of marriage and childbirth. In fact, the medications that are widely used in clinical practice to treat OCD are very safe, have a mild sedative effect, and do not affect intelligence at all. The adverse reactions recorded in the drug’s instructions are also all the adverse reactions observed in clinical trials of the drug in different populations, the chance of them occurring in a particular individual is actually very small, and the vast majority of them are completely manageable. Generally speaking, the more common adverse reactions are gastrointestinal nausea, vomiting, anorexia, diarrhea, etc., as well as dizziness, fatigue, usually in 2-3 weeks after taking the drug gradually alleviated, the vast majority of patients can be tolerated. 2, the need for a full dose of the full course of treatment, maintenance and consolidation of treatment is essential Treatment of obsessive-compulsive disorder drugs are generally slow to take effect, taking 2-3 weeks before the onset of action, so patients should strictly follow medical advice during this period to take drugs, patiently waiting for the onset of action, do not take a very short time to think that it is not effective and stop the drug. A drug needs to be treated for at least 10 weeks in full doses before it can be evaluated as effective. Those who are not effective may be treated with another medication of the same type or another type of medication with a different mechanism of action. Typically, medication treatment for OCD consists of three phases: acute treatment, consolidation treatment, and maintenance treatment. The main goal of the consolidation and maintenance phases is to prevent relapse and to end treatment after stabilization by gradually reducing the dosage to discontinuation. The minimum duration of drug treatment recommended in foreign guidelines is 12 to 24 months. Some patients are eager to get rid of the disease and reduce the dosage or stop the medication as soon as the symptoms are relieved after taking the medication, which will easily lead to relapse. If the medication is withdrawn immediately, there is also a risk of withdrawal reaction due to sudden discontinuation. If the patient stops the medication several times and relapses, the OCD will not be cured and will become chronic intractable OCD, which may require long-term or even lifelong medication with a poor prognosis. Some patients and their families are attracted to Chinese medicine and Chinese herbal medicine, and look to Chinese medicine to treat OCD. So far, there is no proven and effective treatment for OCD in Chinese medicine. Therefore, TCM and herbal medicine cannot be used as a stand-alone treatment for OCD, but can be used as an adjunctive treatment, such as improving sleep. In short, medication should be under the guidance of a professional doctor, and the patient should choose the appropriate medication according to the patient’s actual situation and develop an individualized treatment plan, and the patient should not change the treatment as he or she wishes. 3, rational view of drug treatment OCD is a relatively difficult to treat mental illness, research shows that 54-61% of obsessive-compulsive disorder is a continuous course. Although most patients can benefit from medication, only some patients can be completely relieved after taking medication, while others still cannot be cured. Therefore, patients and their families need to have a rational and calm mindset during the medication process and give up the perfectionist desire to get rid of the “root of the disease” and cure OCD completely. As long as the symptoms are reduced, the quality of life is improved, and social functioning is improved, this is a welcome improvement. For those who are not satisfied with the results, psychotherapy can be combined if necessary to improve the results. For residual symptoms, patients and family members should be able to accept them openly, take the symptoms with them, let nature take its course, and work and live actively.