Sun protection is the basis of treating melasma, and medication should be chosen reasonably on the basis of sun protection. The medicines for melasma include topical medicines and oral medicines, such as hydroquinone, tranexamic acid and so on, but the medicines should be used in accordance with the doctor’s prescription. 1. Topical drugs: Melasma patients can use hydroquinone and its glycoside derivatives, such as hydroquinone, deoxyarbutin and other drugs as prescribed by doctors, which can help local discoloration and thus achieve the purpose of treating melasma. 2. Oral medication: If the symptoms of melasma are more serious, it is necessary to take oral medication such as tranexamic acid, vitamin C and glutathione as prescribed by doctor, which can help antioxidant and reduce hyperpigmentation. Oral medication should pay attention to the adverse reactions. There are many medications to remove chloasma, and patients need to do a good job of sun protection to avoid aggravating the condition. It is recommended that patients go to the regular hospital to consult the doctor, under the guidance of the doctor to use medication, do not take medication without authorization.