Men generally do not need routine folic acid supplementation; however, if a man has a folic acid deficiency, he needs to take a folic acid supplement. Folic acid is a relatively common medication used for various causes of folic acid deficiency, as well as for megaloblastic anemia caused by folic acid deficiency, and for the prevention of fetal neural tube malformations. Folic acid supplementation is usually required for women during the preparation for pregnancy and during the first trimester of pregnancy, while men usually do not need to take folic acid supplementation during the preparation for pregnancy. If a man has a folic acid deficiency that affects the quality of his semen, he needs to take folic acid supplements as prescribed by his doctor, which will help to regulate the quality of his semen and will be helpful in his preparation for pregnancy. However, if you take folic acid for a long period of time, gastrointestinal symptoms such as nausea and bloating may occur, and taking large amounts of folic acid may make the urine appear yellow. If it is vitamin B12 deficiency caused by having red blood cell anemia, it is not possible to use folic acid alone to treat it. If men have folic acid deficiency, it is recommended to actively go to the regular hospital, follow the doctor’s instructions for supplementation, do not take medication without authorization, so as not to lead to adverse consequences.