Most scholars set the best time for surgical revision of cleft lip at 3 months after birth for the sake of surgical safety; while some scholars at home and abroad advocate surgical repair before 3 months; or even as early as one week after birth and achieve good postoperative cosmetic treatment. With the development of obstetrics and gynecology and 4-dimensional ultrasound in China, more and more mothers and fathers-to-be with cleft lip and palate are visiting plastic surgery clinics, and their anxiety and entanglement urge me to share this article with you. With the continuous development and improvement of perioperative techniques such as anesthesia, monitoring, and nursing, we have carried out cleft lip surgery in the neonatal period in recent years, and the level of technology is becoming more and more mature, so neonatal cleft lip repair is no longer off-limits, but neonates are perinatal, and surgery is still risky. We need to understand the advantages of cleft lip surgery in the neonatal period: ① It can correct the lip and nasal deformity of the child earlier and reduce the mental and social pressure of the family; ② It can restore the sucking function of the child as early as possible and create conditions for breastfeeding; ③ It can reduce the chance of respiratory infection in the child; ④ The formation of postoperative scar is significantly reduced in neonates compared with older children; ⑤ It can correct and reduce the rotational misalignment of the alveolar bone on both sides of the cleft; ⑥ It can reduce the hard palate in children with cleft palate at the same time (6) Reduce the width of the hard palate in children with cleft palate, providing good conditions for second-stage cleft palate repair; (7) Provide good conditions for the development of the maxilla on the affected side to be supported laterally. One of the most intuitive and affirmed by the child’s family is that the scar of the lip is almost invisible after 4-5 months postoperatively, which is the most confident point for us to insist on neonatal cleft lip. Nevertheless, not all cleft lip and palate hospitals and doctors are able to perform cleft lip revision surgery in the neonatal period, and there must be special conditions and precautions to reduce surgical risks and accidents: ① the surgeon must have excellent experience in cleft lip and palate revision and surgical techniques, as the anatomical markings of the white line of the lip and the peak of the lip are unclear in neonates; ② an experienced anesthesiologist to cooperate with anesthesia to reduce anesthesia risks in the neonatal period; and ③ High-quality nursing team to provide good care for newborns to prevent postoperative neonatal accidents; ④ Preoperative examination must be comprehensive, paying attention to nutritional development, especially except for the combination of other parts of serious congenital malformations and normal function of organs such as heart and lungs; ⑤ Postoperative temporary can not be directly breastfeeding, apply dropper or spoon feeding to reduce wound contamination; ⑥ Low body mass children and other (6) Low body mass and other conditions that are not suitable for surgical treatment cannot be operated in the neonatal period;