A major triple positive to a minor triple positive is more significant, suggesting that the hepatitis B virus infection is under some control and less contagious. Hepatitis B major triple positive suggests the presence of a more severe hepatitis B virus infection, which tends to have a higher copy number and is more contagious, whereas hepatitis B minor triple positive suggests a lower replication rate, a slower replication rate, and is relatively less contagious. However, this situation is not absolute, and a hepatitis B virus DNA evaluation is required. After the transformation of hepatitis B major triple positive into minor triple positive, if the liver function is normal, the number of hepatitis B virus DNA copies is low, and ultrasonography does not find liver fibrosis or cirrhosis, this is clinically an improvement phenomenon. However, the presence of a high copy number of hepatitis B virus, ultrasound findings of liver fibrosis and high transaminase levels suggest that the condition is still serious. It is recommended to consult the Department of Infectious Diseases or the Department of Gastroenterology of a regular hospital for further diagnosis and treatment under the guidance of a doctor if you have hepatitis B triple positive or triple negative.