Duodenal papillary cancer is the most common malignant tumor of the duodenum and belongs to the category of peri-potty cancer, which is a tumor of medium malignancy. Because it is located at the opening of the common bile duct and pancreatic duct, when the tumor gradually increases, it will compress the jugular abdomen and lead to biliary obstruction and jaundice, pancreatic duct dilatation, and prolonged pancreatic duct obstruction may lead to pancreatic atrophy and acute pancreatitis in some patients. Once the diagnosis of duodenal papillary cancer is confirmed, radical surgery should be performed as soon as possible. If the tumor is small and does not invade the surrounding tissues and there is no lymph node metastasis, abdominal resection (duodenal papilla and abdomen) is feasible, and the severed ends of the common bile duct and pancreatic duct are sewn to the duodenal wall. According to foreign literature, there is no significant difference in 5-year survival rate with pancreaticoduodenectomy. If the tumor has invaded the head of the pancreas and the middle and lower part of the common bile duct with surrounding lymph node metastasis, radical pancreaticoduodenectomy should be performed.