Nevus is a very familiar and most common disease. On average, 15-20 nevi exist on the body surface of normal people, and the vast majority of them are distributed on the skin, while a few can also be distributed on the mucous membranes covered by squamous epithelium such as the oral cavity and vagina. Most nevi appear in the second to sixth year after birth, and almost all nevi on the body have been revealed by the age of 20. The size of moles varies from a few millimeters in diameter to large ones that can occupy the entire face and torso. As the size of a mole increases, it becomes more difficult to treat. Small nevi can be directly excised and sutured, while larger ones can be repaired by implants, expanders, local flaps and other methods, all of which can achieve better results. Then how to treat those nevi that occupy the whole face and torso? Giant congenital melanocytic nevus, referred to as giant nevus, is a kind of congenital melanotic nevus characterized by a huge nevus area. Medically, a nevus with an area of 144cm² or more, or a diameter of more than 20cm, or an area of more than 900cm² on the limbs or trunk, in any part of the body, can meet the diagnostic criteria for a giant nevus. Of course, the diagnosis of giant nevus cannot depend on the size of the absolute area, and its relative size should also be considered in conjunction with the patient’s body surface area. If the lesion covers special areas such as eyelids, ears, hands, etc., forming a larger impact and requiring higher restoration, it can also be called a giant nevus if the area is smaller than the above criteria. Giant nevus exists at birth, often distributed according to skin zoning features, and can involve the whole limb, the whole scalp, shoulder, large part of the trunk, or even appear in the placenta at the same time, shaped like a cap, boot, shoulder pad, swimsuit or stocking, tan, black or uneven color, soft texture, uneven height, rough and fat, also can have hair growth, and there are often warty or nodular changes on the nevus. In other parts of the body, many small scattered satellite foci are often seen. Those occurring on the scalp and neck may be accompanied by soft meningeal melanocytic hyperplasia, and may also involve the skull, presenting with epilepsy, mental developmental disorders, and combined with primary soft meningeal melanoma. Regarding the malignancy rate of giant nevi, the probability of developing malignancy varies from 1-12% according to the results of prospective follow-up. Therefore, close follow-up of patients with giant nevi is important, and malignant changes usually occur within the giant nevus lesion or occasionally at satellite foci. Some foreign scholars believe that patients with giant nevi should be considered for early excision after birth, even in infancy, to prevent malignant changes. Parents of children with giant nevus often feel anxious and apologetic about their children, trying to cure them at all costs, while feeling inferior and afraid to let them face their friends and relatives. As the child grows day by day, he or she is under great mental pressure and often discriminated against by others, so they strongly hope to get treatment. What is the effect of treatment for giant nevus? The traditional treatment for giant nevus can only be repaired by removing the lesion and then taking skin implants from other parts of the body, or by embedding skin expanders and using expanded flaps or cutting the expanded area for skin implants. The larger the area of the nevus, the larger the area of skin to be removed and the larger the scar left behind. In some children, the nevus is so large that the body cannot provide enough donor area for skin grafting. Regardless of the scar left after skin removal, even if the skin grafting surgery is successful, the color and texture of the living skin piece will be very different from the surrounding normal skin. Usually, the skin grafting area is of varying shades of brown in color, thin and brittle in texture, and there are relatively obvious suture scars at the edges of the grafting area. As a result, these methods cannot achieve good results, and often the recipient area has unsatisfactory results and the donor area has very obvious scarring, resulting in lifelong regrets for parents and children. Recaell technology is a new international technology for the treatment of scar and pigmented skin diseases, and has been used to achieve excellent results in all areas of the body for scar, scar pigmented changes, and superficial wound repair methods. Our center has also been the first in China to apply Recell technology for facial scar treatment, and has achieved good results. According to the experience of international counterparts and our practice, according to the “drop principle” of nevus growth, combined with the application of Recell technology, we can treat infantile giant nevus very well. The “drop principle” of nevus growth means that the growth of nevus is downward and deeper, in infancy, nevus is mostly junctional nevus, the nevus is located at the junction of epidermis and dermis, in middle and old age, nevus is mostly intradermal nevus, the nevus is completely located in the dermis, and the nevus located in between is called ” mixed nevus”, where the nevus is located in the above two parts. When the depth of skin abrasion is in the superficial layer of epidermis and dermis, it can heal by itself and does not leave a scar after healing. This is the same principle as the skin abrasion and scabbing, after a period of time the scab falls off and normal skin appears. Thus, the junctional nevus component of giant nevi can be completely removed by applying grinding techniques during infancy and childhood. However, after simple grinding treatment, it takes 2 weeks for the wound to heal, and due to the characteristics of Oriental skin, pigmentation and pigment loss are very likely to occur, etc. With the Recell technique, a 1×1 cm piece of normal skin of the body is taken and put into a special kit to make a skin cell suspension covering 80 cm² of the body. The risk of pigmentation changes is also greatly reduced. Thus, this is the best method for treating congenital nevus. With minimal damage, only the trauma of the area to be treated for the nevus and the 1-2 cm² Recell donor trauma, the best results are achieved, with the new skin being closest to the surrounding tissue and without the unsightly suture scar left after the removal of the nevus and the skin implant. This procedure requires general anesthesia. Many parents worry that anesthesia will harm their child’s intelligence, which is actually a complete misconception. Modern anesthesia techniques not only do no damage to a person’s intelligence, but are also very safe. The procedure can be performed safely on the second day after birth.