Patient Question: Disease: Chronic Granulocytic Leukemia Description: My mother, who is sixty-one years old, was diagnosed with chronic granulocytic leukemia three years ago and was taking Gleevec from India after diagnosis. The patient has been taking Gleevec since then and is living her life as usual with no major adverse effects. The patient has been taking two capsules a day, sometimes one capsule a day, because the usual blood count has always been low, about 3500-5000 white blood cells. The patient has been taking two capsules a day, sometimes every day. The reason why I am saying this is because when we went to the hospital for consultation, some doctors said that we were taking fake drugs once they heard that we were taking Indian ones. Who can understand the feelings of the patient who can understand the feelings of the patient’s family. It is really very helpless. I have two questions: First, is it possible for my mother to continue to take two capsules or one capsule per day with normal blood count, because the recommended minimum maintenance dosage is three capsules. Is there any relevant clinical guideline data? Secondly, the absence of recurrence for several years after conversion means that the patient’s chances of getting the disease again are the same as those of the general population? Please reply to my question in your busy schedule, thank you very much! Duan Minghui replied: Even if it is true, it is necessary to take sufficient amount of long-term treatment, less than 3 capsules per day will lead to gene mutation and treatment failure! Be sure to check the peripheral blood fusion gene quantification every three months, this is very important to determine the efficacy and predict the future outcome. Theoretically you can’t stop treatment, but new research has found that some patients can eventually stop treatment without relapse, but it usually takes 5 years of treatment before you can try, and, pre-treatment needs to be very compliant with medical advice, and you may end up losing the chance of curing the patient with such a three-day, two-day treatment!