Most chronic osteomyelitis develops as a result of inadequate or untimely treatment of acute osteomyelitis. However, if the virulence of the causative agent of acute osteomyelitis is low, or if the patient is more resistant, it is possible to start with subacute or chronic osteomyelitis, and osteomyelitis from skin wound infections is often chronic from the beginning. The causative agent of chronic osteomyelitis is also Staphylococcus pyogenes. In those with chronic sinus tracts, there is often a mixture of bacteria. The disease occurs in the epiphysis of the long tubular bone in children. Most have a history of acute osteomyelitis, a history of open fracture infection, recurrent or prolonged acute inflammation, recurrent sinus tract drainage, and a history of small pieces of dead bone draining from the sinus tract. Clinically, it is characterized by sinus tract drainage, dead bone and dead cavity, and limb deformity. Some patients may develop squamous epithelial carcinoma in the skin near the sinus tract due to long-term irritation by secretions over time. Amyloidosis may also develop in organs throughout the body due to long-term consumption. The disease is mainly treated by surgery. The healing process is achieved by surgical removal of dead bone, elimination of dead cavity, and removal of the sinus Lou tube. There are still some cases of limb dysfunction or disability after amputation due to malignant lesions after treatment. Therefore, the key to treatment in the acute stage.