Chronic osteomyelitis is now mostly seen after fracture surgery or severe trauma, and is the most annoying and distressing outcome for almost every orthopedic surgeon, but unfortunately, with the increasing number of vehicles, frequent traffic accidents (China has been the country with the most traffic accidents in the world for 10 years in a row), and improper treatment, there is a gradual increase in the number of patients with chronic osteomyelitis, and until about a decade or so ago chronic osteomyelitis often required amputation. However, with the increasing understanding of the disease, a large number of groundbreaking treatment concepts and tools have been applied in the clinical setting, and very promising results have been achieved, especially in the control of inflammation and late limb reconstruction is a breakthrough progress, fully demonstrating the wisdom and hard work of the majority of doctors and researchers. Amputation of limbs due to chronic osteomyelitis is now rarely seen! However, it is still very difficult to get rid of the recurrent attacks of chronic osteomyelitis, the daily flow of pus from sinus tracts and the non-functional status of the affected limb, and the treatment period is usually long. The good thing is that patients are generally able to understand the longer treatment period. Unfortunately, there are not many doctors in China who can truly understand and master these concepts and treatment methods, resulting in many patients with chronic osteomyelitis not receiving timely and effective treatment, and having to accept the advice of “some doctors”: there is no cure for your disease anymore!