Chronic osteomyelitis is a common disease in orthopaedics, and also a famous “difficult disease” in orthopaedics. Many patients suffer from chronic osteomyelitis due to systemic infection or post-traumatic infection, which is not cured and is very painful, and they are often operated for many times, and even amputated due to cancerous transformation of tissues or loss of limb function because of the infection which does not cured. We utilize microsurgical techniques to cover the osteomyelitis wounds with tissue flaps that have rich blood flow and strong anti-infection ability on the basis of thorough removal of the infected lesions, as well as internationally advanced local slow-release antibiotic technology and negative pressure treatment of the wounds. Combined with the use of advanced external fixation bracket, to achieve the removal of the lesion, tissue repair, trauma coverage, fracture and deformity correction of multiple therapeutic purposes, the clinical efficacy of satisfactory, the following picture case form for everyone: Peking University Shenzhen Hospital, hand, microsurgery, Zhou Hammer, nuclear magnetic resonance of the right femur infected foci of MRI show tibial osteomyelitis foci of drainage of tibial osteomyelitis foci of drainage of the following chart shows the pathway of osteomyelitis infection of the two typical below Case 1 case 2 ankle closed fracture 3 years after surgery, chronic osteomyelitis, outside the hospital has been nine operations, on the verge of amputation foci removal antibiotic slow-release preparation implantation design free composite tissue flap repair trauma recovery after surgery, we recommend that the patient in the outpatient clinic, the author has many years to deal with intractable wounds surgical experience, and at home and abroad a number of trauma treatment centers visit exchanges, and I hope to give this kind of patients hope for the treatment. We hope to bring hope to these patients.