[Abstract] OBJECTIVE: To summarize the efficacy of applying anterolateral femoral penetrating flap for the treatment of cutaneous soft tissue defect trauma in chronic osteomyelitis of the lower leg. METHODS: A total of 10 cases of chronic osteomyelitis of the lower leg combined with skin defect trauma were treated with anterolateral femoral penetrating flap graft. RESULTS: All 10 flaps were viable at postoperative follow-up of 4 months-2 years. The infection healed in 9 cases and recurred in 1 case. CONCLUSIONS: The application of anterolateral femoral penetrating flap combined with negative pressure drainage technique for the treatment of chronic osteomyelitis skin defect wounds in the lower leg can effectively control infection with less damage to the flap donor area and good appearance of the recipient area, which is a practical and effective method. Hammer Zhou, Department of Hand and Microsurgery, Peking University Shenzhen Hospital [Keywords] chronic osteomyelitis; skin defect; anterolateral femoral penetrating flap. curative effect observation on transfer of free anterolateral thigh flap in treatment of chronic lower leg osteomyelitis and soft tissue defect.[Abstract] Objective: To evaluate the clinica1 outcomes of free anterolateral thigh flap in treatment of chronic lower leg osteomyelitis and soft tissue defect.Methods:We retrospectively reviewed 10 patients who underwent free anterolateral thigh flap We retrospectively reviewed 10 patients who underwent free anterolateral thigh flap transfer with VSD technique for post-traumatic osteomyelitis.Results: All the wounds were healed by first intention. A follow up 4 -24 months Conclusion: Chronic lower leg osteomyelitis can be successfully treated by free anterolateral thigh flap transferred with VSD technique. Conclusion: Chronic lower leg osteomyelitis can be successfully treated by free anterolateral thigh flap transferred with VSD technique.[Key words] chronic osteomyelitis; skin defect; anterolateral thigh flap. We used the leading microsurgical technique in China to remove the osteomyelitis lesion and repair the refractory trauma at the same time, achieving better clinical results and bringing hope for limb preservation treatment for such patients.