In the treatment of chronic osteomyelitis, phase I debridement, opening and drainage, and lavage are commonly used, but are often ineffective. Second-stage autologous bone grafting has been the gold standard for filling bone defects, but its source is limited and it is often resorbed or becomes dead bone when the inflammation is not adequately controlled. Allogeneic bone, on the other hand, can solve the problem of insufficient volume but has the potential to cause an immune response or aggravate infection. The advent of antibiotic bone cement, especially the use of antibiotic chains, has provided a new way to treat osteomyelitis. However, because it is non-resorbable, it becomes a foreign body at the site of the lesion and requires surgical removal followed by bone grafting. In recent years, doctors have devoted more attention to calcium sulfate and calcium phosphate bone powder, which are biocompatible, degradable and injectable, and can carry drugs, making them more and more widely used in clinical practice. Treatment methods (divided into 2 phases) Phase I treatment: 1. Soft tissue lesion excision and necrotic bone removal. The lesion area is supplemented with external application of traditional Chinese medicine. 2.Open window drainage of diseased bone (iliac bone, heel bone). 3.Irrigation (tibia, femur), for sclerotic bone use grinding drill to polish its surface treatment. 4.For the medullary cavity that has been closed by long tubular bone, chisel the medullary cavity during reaming. 5.Add antibiotic chain or antibiotic bone cement to the medullary cavity first as a transitional stage of anti-inflammation, while placing the canal for lavage. 4-6 weeks later, remove the cement again surgically. 6, again to clear and expand the wound. 7.Bacterial culture and drug sensitivity test are routinely done before surgery. Topical and internal herbal medicines were given according to the evidence during the treatment. Phase II treatment: 1. All cases were routinely treated in phase I for about 4 weeks-6 weeks. 2.After the local lesion is free of redness, pain and purulent exudation, the wound is filled with drug-laden antibiotic bone powder according to the culture results and the wound is closed in phase I. 3.An example of the ratio of antibiotic to bone powder is 5g of Stix bone powder plus 0.8g of vancomycin. Depending on the size of the lesion, the amount of drug-laden bone powder used varies from 5g-30g. 4, self-prepared drug-laden vancomycin bone powder method and usage: according to the usage of Sidi calcium sulfate bone powder, 5g of bone powder added to 0.8g vancomycin. The amount of antibiotic is added in multiples with the amount of bone powder, which will not have any effect on the strength of the bone powder after solidification. First, remove the antibiotic chain to clear the lesion again, observe the fresh bone around the lesion, rinse and swab the lesion area. Take the sterile package of bone powder, add the corresponding multiples of antibiotics, mix it with the dilution in the package to a paste, and fill it into the lesion within 6 minutes.