Bilateral calf interosseous vein thrombosis is generally not particularly serious, but it can be dangerous. Bilateral calf interosseous vein thrombosis, also known as gastrocnemius vein thrombosis, is usually characterized by pain and swelling of the calf. However, in the acute stage of intermuscular venous thrombosis, it is also necessary to cooperate with the doctor to guide the targeted treatment. Acute bilateral calf interosseous vein thrombosis, in the early stage of the onset of anticoagulant therapy in a timely manner, you can follow the doctor’s instructions oral anticoagulant, such as rivaroxaban, edoxaban, etc., the majority of patients can achieve the purpose of the cure. If the patient is not timely control and treatment, in the acute phase of bilateral calf intermuscular venous blood, it is likely to develop into venous thrombosis or popliteal vein thrombosis. These thrombus dislodgement, may form a fatal pulmonary embolism and other emergencies, therefore, should pay attention to the disease, has been diagnosed, need to comply with the doctor’s instructions in a timely and effective treatment and care.