Neonatal jaundice with the following characteristics requires prompt medical attention: 1. Premature infants: Premature infants at <37 weeks of gestation have the potential for permanent neurological damage at milder degrees of jaundice due to the presence of multiple high-risk factors, and therefore require prompt medical attention. 2, jaundice appearing within 24 hours: jaundice appearing in this time period needs to be alerted to the possibility of neonatal hemolytic disease, such as ABO hemolytic disease and Rh hemolytic disease. These diseases can lead to faster progression of jaundice, and some children need blood exchange treatment. Especially when the mother's blood type is O or Rh negative, the father is other blood type of children, more attention should be paid. 3, jaundice that progresses relatively quickly: general physiological jaundice daily bilirubin rise < 85umol/L (5mg/dl), if the jaundice progresses significantly higher than this rate, or the naked eye observation of the child jaundice within a short period of time significantly aggravated, need to promptly seek medical advice. 4, jaundice with delayed remission: jaundice generally recedes in full-term infants in 2 weeks, and can be delayed to 4 weeks in premature infants. If the jaundice does not subside after this time point, you need to see a doctor to find the cause of the jaundice. Of course, breast milk jaundice is the most common, but need to exclude some infectious diseases, or hepatobiliary system diseases. 5, jaundice receding and reappearing: generally jaundice will gradually subside after reaching a peak in 4 to 5 days, if the jaundice worsens in the process of subside, it is necessary to seek medical attention in a timely manner. 6, accompanied by other manifestations: such as accompanied by significant weight loss or no weight gain after 10 days, fever, decreased milk, poor response, cough, abnormal color of stool, pale face, cranial hematoma, delayed discharge of fetal stool (usually solved within 24 hours and turned yellow in 3-4 days), or family history of G-6-PD deficiency and other abnormal manifestations. 7. Those with perinatal high-risk factors: mother with fever at delivery or before delivery, history of premature rupture of membranes, history of asphyxia in the newborn, etc.