Lobular hyperplasia is the most common type of non-neoplastic, non-inflammatory proliferative lesion among breast hyperplastic diseases, accounting for about 70% of breast diseases, and can occur in women of any age after puberty. Etiology There are many causes of lobular hyperplasia of the breast, but it is mainly related to endocrine disorders or mental and emotional disorders. Once the ovarian function is affected by certain factors, such as emotional instability, mood discomfort, overwork, sexual disharmony, changes in living environment, or excessive consumption of hormone-containing tonic products and long-term use of hormone-containing cosmetics, etc., the ratio of estrogen and progesterone secretion in the body is out of balance or the secretion rhythm is disturbed, causing breast tissue Hyperplasia. The main clinical manifestation of lobular hyperplasia is: 5-7 days before the onset of menstruation, breast swelling and pain, the onset of menstruation breast swelling and pain relief, or even disappear, to be the next menstruation before the onset of the cycle of changes. Examination 1, the correct breast examination touch the palm of the hand should be flat four fingers together, with the most sensitive index finger, middle finger, ring finger end fingers in order to lightly search the outer upper outer breast, inner lower, inner upper area, and finally the nipple and areola area in the middle of the breast. Do not use your fingers to grasp and pinch the breast tissue during the examination, otherwise the grasped breast tissue may be mistaken for a lump. 2.From sitting position any nipple inversion skin depression structure shape abnormality is a clue of deep breast cancer. If the patient claps her hands on her head to contract the pectoral muscles, the above signs will appear, and when the woman is in sitting position, it is easy to check the lymph nodes above and below the clavicle and in the axilla. Finally, palpation should be performed while sitting, and the area under the nipple should be touched with joined fingers. 3, breast examination should first observe the development of the breast. Whether both breasts are symmetrical in size and similar, whether both nipples are on the same level, whether there is retraction of the nipple depression; whether there is erosion of the nipple areola, how the skin color of the breast is, whether there is edema and cellulite-like changes whether there is inflammation such as redness and swelling, whether the superficial veins in the performance breast area are angry, etc. 4.Ultrasound examination: When a lump is suspected in the breast, ultrasound examination is a must. This is a preliminary screening test for breast lumps and can be used to determine the nature and location of the lump. However, it is less able to identify lumps under 1 cm in diameter, and smaller lumps may be missed if this test is done alone. 5.Infrared scan: Infrared scan is especially suitable for screening women during pregnancy and breastfeeding. This test uses the difference in infrared absorption between normal and diseased tissues to diagnose breast disease by displaying different grayscale images of translucency and darkness. Because this test is fast and non-radioactive, it is often used as a primary screening test for breast disease in medical examinations. Although it is not a specialized examination of the breast, it can still be used as a screening test for breast lesions. Diagnosis Lobular hyperplasia (the second stage in the progression of breast enlargement) is a common disease among young and middle-aged women aged 25 to 40, with an incidence of about 5%. It may be detected before menopause in 1 out of 20 people. It is neither a tumor nor an inflammatory disease, but a result of structural changes in the ducts and lobules of the breast caused by female endocrine disorders. If a woman does not marry, have children, or breastfeed at a certain age, she is prone to endocrine disorders that cause hyperplasia at the ends of both mammary glands. Analysis of a large amount of clinical data shows that lobular hyperplasia should be diagnosed differently from fibroadenoma and breast cancer. Lobular hyperplasia, also known as cystic mastopathy, is one of the most common diseases in women, and lumps found in the breast are the main reason why patients visit the clinic. The lumps are often multiple and can be confined to one breast or diffuse in both breasts. The masses are granular nodules, ranging from small sesame seeds and green beans to large lumps that lack distinct borders and do not adhere to the skin or deeper tissues. Patients often have varying degrees of breast tenderness, which is cyclical and related to the menstrual cycle, with the tenderness being worse before menstruation and less afterwards. Lobular hyperplasia and mammary fibroadenoma: Both can be seen as single or multiple breast lumps with a firm texture. Most of the breast lumps in lobular hyperplasia are bilateral, with different sizes, nodular, lumpy or granular, generally soft, but also hard and firm, occasionally unilateral and single, but mostly accompanied by premenstrual breast swelling and pain when touched, and the size and nature of the breast lumps can change periodically with menstruation. Most breast lumps in fibroadenoma are unilateral, round or ovoid, with clear borders, high mobility, and generally firm texture, but there are also multiple breast lumps, but there is usually no breast pain, or only mild menstrual breast discomfort, no tenderness, and the size of breast lumps does not change according to the menstrual cycle. In addition, on mammograms, breast fibroadenomas often appear as round or ovoid shadows with a characteristic ring-shaped transparent halo, which can be an important basis for differential diagnosis. Lobular hyperplasia and breast cancer: Breast lumps can be seen in both cases. However, breast lumps in lobular hyperplasia are generally soft or moderately hard in texture, mostly bilateral, varying in size, nodular, lumpy or granular, mobile, and not adherent to the skin or surrounding tissues. The lump may be round, oval or irregular in shape, and may grow to a large size, with poor mobility and easy adhesion to skin and surrounding tissues. In addition, on the mammogram of breast, breast cancer often appears as lump shadow, tiny calcified dots, abnormal vascular shadow and burr, which can also help in the diagnosis. Mass needle aspiration of breast cancer can find heterogeneous cells. The final diagnosis needs to be based on the histopathological examination results.