High diabetic urine protein is considered to be caused by diabetic nephropathy, which can be treated by general treatment, medication and renal replacement therapy. 1. General treatment: improve lifestyle, including diet therapy, exercise, smoking cessation, alcohol restriction, salt intake restriction, weight control, etc., which is conducive to slowing down the progression of diabetic nephropathy and protecting kidney function. 2. Medication: Under the instruction of doctor, we can use glucose-lowering drugs such as Dagliflozin and Liraglutide to control blood sugar. When diabetic nephropathy patients have high blood pressure at the same time, they can take Irbesartan, Captopril and other antihypertensive drugs to control high blood pressure and reduce proteinuria. 3. Renal replacement therapy: If diabetic nephropathy patients develop to end-stage renal disease, they can choose renal replacement therapy, such as dialysis, kidney transplantation and so on. High urine protein in diabetic patients may also be caused by other reasons, such as glomerulonephritis, interstitial nephritis, urinary tract infection and other diseases. Diabetic patients with high urine protein should be diagnosed and treated under the guidance of a physician to avoid delays.