Recurrence of chronic hepatitis B is a common phenomenon that doctors encounter in the treatment of hepatitis B. There is no way to eliminate recurrence, but there are ways to reduce or prevent it. Although there is no way to eliminate hepatitis B relapse, there are ways to reduce or prevent it. We have analyzed 100 cases of chronic hepatitis B relapse and identified a number of triggers that contribute to relapse. Among them, “random medication” is the first trigger. The specific manifestations of random medication: randomly stopping medication, randomly adding medication, randomly missing medication, randomly increasing or randomly decreasing medication, etc. For example, some people take one antiviral drug every other day (while the regulations are once a day), or take one tablet every two days or only half a tablet a day (while the regulations are 1 tablet each time), saying that in order to reduce toxicity; some people take 2 tablets each time, saying that in order to quickly kill the virus; some patients will be on business trips, home to visit relatives or travel, stopping the drug for several days in a row; more are taking 6 months to stop the drug, since Some patients stop taking the medication after 6 months, thinking that half a year is a course of treatment; some other patients “accept it when it is good” and lose contact with the doctor after the symptoms improve, and do not come to the doctor until the disease relapses. The irregular use of medication gives the hepatitis B virus a chance to “catch its breath”, so that it can not only multiply rapidly, but also has the opportunity to mutate. The dosage and course of antiviral drugs are the result of repeated research and testing by scientists and have been proven in most patients. Therefore, patients must standardize their treatment, i.e., follow the medical advice and “never stop until the goal is achieved”, which is an important part of reducing the recurrence of hepatitis B.