Hepatitis B carriers are those who are found to be hepatitis B two-to-one positive (commonly known as major or minor triplets) but have normal liver function (ALT, AST). What should I pay attention to for hepatitis B carriers? How to prevent, reduce and delay the occurrence of cirrhosis? This is the main concern of clinicians and netizens. Hepatitis B carriers who have been positive for more than six months are chronic hepatitis B carriers. The following aspects should be paid attention to in order to reduce or delay cirrhosis. First, life and diet: usually pay attention to not overeating, prohibit drinking all kinds of alcohol, less smoking. Do a combination of work and rest in life, to avoid overwork. Diet: do not eat fried, barbecued and pickled food, more nutritious food such as a variety of vegetables, soy products, fresh fish and meat. Drink less beverages and canned goods to prevent liver damage from excessive preservatives. Second, regular check liver function, liver, gallbladder and spleen ultrasound examination, required once every six months to a year. Third, adhere to standardized antiviral therapy: when liver function abnormalities (ALT) greater than 60u, for 2 consecutive weeks does not drop. The first choice is to exclude alcohol consumption, the use of liver-damaging drugs or fatty liver, etc. The hepatitis B virus should be considered to cause liver damage (ALT elevation). Hepatitis B virus nucleic acid (HBV DNA) should be checked promptly. If HBV DNA is positive and ALT is abnormal, anti-hepatitis B virus treatment (nucleoside drugs lamivudine, adefovir, interferon and other standard treatment) should be promptly. What should I pay attention to during long-term antiviral treatment? The only means to reduce cirrhosis is to adhere to long-term antiviral treatment for chronic hepatitis B. However, attention should be paid to regular monitoring of liver function and liver function. If the HBV DNA changes from positive to negative after the medication is administered, and then changes from negative to positive without stopping the medication, we should analyze whether it is a laboratory error or drug resistance. If it is drug resistance, it is up to the treating physician to add or switch to another antiviral drug. Lessons learned: I met a patient who came to the hospital for review after a year of intermittent lamivudine and was positive for HBV DNA, and it was difficult for the doctor to analyze whether it was drug resistance or relapse after stopping the drug. I have also seen many patients who have been on adefovir for more than 1 year and still have positive HBV DNA when they come to the hospital for recheck. HBV DNA has not been checked since taking the drug, and it is also difficult to distinguish whether it is ineffective or resistant. These are lack of post-drug management. How to choose nucleoside analogues? When to stop the drug? I have mentioned in several articles above please refer to the internet. Why is cirrhosis caused by hepatitis B terrible? What is the lesson? In 2012, 74 patients with hepatitis B cirrhosis were admitted to our hospital and half of them had hypersplenism and ascites. The percentage of patients with concomitant portal hypertension and upper gastrointestinal bleeding was 40%, and the percentage of patients with hepatic coma was 20%. Eighty percent of them lost their labor force, mostly young adults. Before admission, 90% of the above patients were treated with Chinese herbal medicine outside the hospital for a long time, and only 10% were treated with non-standardized antiviral therapy. The most painful lesson is not antiviral treatment. A word of advice to the network: acquire more scientific knowledge. Antiviral experience: The authors have adhered to antiviral treatment for chronic hepatitis B in more than 3,000 cases in recent years, with 5 years of follow-up, and 30% of cumulative relapses after discontinuation, but no case of cirrhosis. The authors believe that: adherence to regular, continuous antiviral therapy for at least 2 years, and failure to meet the conditions for drug discontinuation, should continue antiviral is the only way to reduce cirrhosis of hepatitis B.