It is generally accepted that the occurrence and development of asthma in children is closely related to genetic factors as well as various environmental factors. Based on the presence of atopic constitution, various environmental irritants cause respiratory hyperreactivity and chronic inflammation through inflammatory cells and the cytokines they produce, thus belonging to a common allergic disease. At the same time, it has been found that there is an association between obesity and the development of asthma in children. Flaberma et al. analyzed the literature and data and found that being overweight at birth or in childhood increased the risk of asthma later in life, with being overweight in childhood increasing the risk of asthma later in life by 50% and being born with a high birth weight increasing the risk of asthma later in life by 20%. Carroll et al. found that… Obese children with asthma have more asthma symptoms and require more emergency care and longer resuscitation times than non-obese children. Thus, it is suggested that prospective studies on the effect of weight loss on asthma will lead to a better understanding of the relationship between obesity and asthma. In recent years, the prevalence of asthma in children in China has been increasing year by year and has become a major health threat to children. In addition, the prevalence of childhood asthma is increasing year by year. This suggests that obesity is also a high-risk factor for the development and aggravation of childhood asthma in China. Based on this, the author hypothesized that weight control may be beneficial to improve the efficacy of asthma medication and improve the clinical prognosis of patients. The study found that the comprehensive obesity intervention program was effective in controlling the children’s body weight, and at the same time, the rate of complete control of asthma, the significant rate and the overall efficiency of the experimental group with the comprehensive weight intervention program were significantly increased compared with the control group with drug treatment alone (P<0.05), and the improvement of respiratory function was also significant (P<0.05), suggesting that weight control is important for improving the clinical prognosis of asthma medication in children. This suggests that weight control has an important role in improving the clinical prognosis of asthma medication in children. Since obesity in children in China is also showing a rapid growth trend, the Chinese Academy of Pediatrics has developed the "Childhood Obesity Guidelines". The Chinese Academy of Pediatrics has formulated the "prevention and treatment routine of childhood simple obesity" and recommended comprehensive measures such as "behavior modification, moderate exercise, and diet adjustment" to control childhood obesity. He Yifeng et al. reported that the total effective rate of comprehensive interventions to control the weight of obese children was 91.7%, and the total effective rate of interventions to control the weight of obese children was 85.8%. The two are basically similar, indicating that comprehensive intervention programs are effective measures to control the weight of obese children. It was found that obesity has adverse effects on both the upper and lower airways, leading to pulmonary restrictive ventilation dysfunction and pulmonary diffusion impairment. After correcting for other factors such as congenital allergies, age, gender, smoking and family history, BMI becomes an independent determinant of asthma and cough in children. Since the effects of obesity on lung function are usually reversible, lung function will improve with weight loss. Therefore, it is hypothesized that the effect of weight control on improving asthma medication in obese children may be achieved by restoring lung function. In conclusion, a comprehensive weight control intervention program can effectively reduce the weight of obese children, thereby increasing the responsiveness of obese children to pharmacotherapy, reducing the recurrence rate of asthma and improving lung function, which is important for improving the efficacy of asthma pharmacotherapy and improving the clinical prognosis of asthma.