The first choice of antidote for atropine poisoning is trichothecene and salicylate lentil base, and the specific first aid measures depend on the severity of the patient’s poisoning, as well as the clinical symptoms. In general, low-dose subcutaneous injections of trigonelline at 6-8 hour intervals are sufficient for mild atropine poisoning.
For moderate to severe atropine poisoning, immediate medical attention should be sought and the patient’s vital signs should be stabilised under medical supervision before the frequency of antidote injections is increased to 20-30 minutes until the patient’s symptoms have subsided and vital signs have stabilised.
For some patients with particularly severe atropine poisoning, the effect of interventional drug therapy alone is limited and timely haemofiltration therapy and plasma replacement therapy are required. Once symptoms are stabilised, the excretion of atropine from the body can be facilitated by fluids and diuresis.