Many chronic diseases require long-term medication due to their long course and slow response, and often patients will experience vision loss at a later stage. “It is a medicine three points poison”, which are common drugs that may damage vision? 1, hormones: either orally or topically spotted, such as a course of more than 2 to 4 weeks, can cause an increase in intraocular pressure and lead to glaucoma, which generally takes several weeks to recover after stopping the drug. It can also cause debris-like or vacuolated clouding of the lens and cataracts. Glucocorticoid drops can also cause slow healing of corneal wounds, and may also induce mid-pulp. 2, chloramphenicol: general adults with 1 to 2 grams per day, for a month can cause toxic optic neuritis. After discontinuation, some patients can be improved, but some patients can develop optic nerve atrophy, or even blindness, especially in children is more likely to occur. Chloramphenicol can also cause acute toxic epidermolysis bullosa, causing eyelid adhesions and pseudomembranous corneal scarring. For allergic patients, even the application of chloramphenicol eye drops can cause allergic conjunctivitis. 3. Streptomycin: In addition to acute toxic epidermolysis bullosa, it can also damage the optic nerve, causing sudden retrobulbar optic neuritis or progressive optic nerve atrophy. Allergic patients may develop periorbital edema and conjunctivitis. 4. Ethambutol: Recently, it is believed that retrobulbar optic neuritis, retinal hemorrhage and pigmentary changes, such as reduced visual field, red-green discriminatory power, and loss of vision can occur in severe cases, especially when applied in high doses. The above damage is more likely to occur in people with poor renal function. 5.Isoniazid: In addition to acute toxic epidermolysis bullosa, it can also cause optic neuritis and optic nerve atrophy. It can be recovered after stopping the drug. If used in combination with vitamin B6, the incidence of eye damage can be reduced. 6, aspirin: can cause bleeding in both eyes. 7, anti-inflammatory pain: can cause blurred vision and blindness, retinopathy and corneal stromal clouding, etc. 8, chlorpromazine: long-term application of large amounts can cause toxic retinopathy, such as the appearance of similar pigmentary retinitis, visual acuity loss, visual field defects. 9, Valium: It can cause acute attacks of closed-angle glaucoma, increased intraocular pressure and decreased visual acuity. In short, patients with long-term high-dose medication should pay close attention to the various symptoms that appear in the eye and ask for a doctor’s diagnosis or specialist consultation to avoid causing serious visual impairment.