The reasons for chest tightness and shortness of breath once you work are as follows: First, consider coronary heart disease, unstable angina. Patients with angina present with chest tightness, shortness of breath and shortness of breath after activity or exertion, and can do electrocardiogram and cardiac ultrasound to clarify the diagnosis. Second, consider heart insufficiency, especially valvular heart disease, such as rheumatic heart disease, senile valvular heart disease after exertion, chest tightness, dyspnea, can do cardiac ultrasound examination to clarify the heart structure. Third, a work on chest tightness, shortness of breath, to consider chronic obstructive pulmonary disease, most of them are related to long-term smoking, patients show chest tightness, dyspnea, prolonged wheezing after activity, can do lung function test to clarify the diagnosis.