The autologous epidermal transplantation does not require anesthesia and hospitalization, which is simple and easy to perform and promote; the efficacy is sure and fast, and because the dermis is not injured, no scar is formed, which is a more ideal method to treat stable limited or segmental vitiligo. The method is to use the principle of negative pressure attraction to transplant the epidermis layer of the normal part of the skin in the white spot lesion area to increase the number of melanocytes in the lesion area. Generally, a porous suction cup is placed on the vitiligo patient’s skin lesion and the skin donor area, while the negative pressure of 30-60kPa is used to attract the blistering, so that the epidermis and dermis are separated. The blistering process generally takes about 30-90 min, and local heating can accelerate the blister formation. After blistering, the blistering epidermis is removed from the white spot, and the blistering epidermis from the donor area is laid flat on the exposed surface of the white spot and wrapped with pressure. 2 weeks later, the transplanted epidermis becomes viable and pigmentation is generated, and 4 weeks later, the melanin deepens and expands, and the pigmentation expands to the maximum in 3-6 months. In some special areas of white spots, such as the nasal forehead, perioral area and uneven areas such as joints, where it is difficult to absorb the suction cup, grinding can be used to grind away the epidermis and then transplant the normal epidermis on it. Blistering can also be induced by liquid nitrogen freezing, 10% spotted alcohol or excessive ultraviolet light method in the skin-receiving area. The skin pieces should not be too far apart when transplanting to avoid the formation of splotch-like appearance or punctate pigmentation, and traction and friction should be avoided after transplantation to improve the survival rate of transplanted skin pieces.