Diabetic neuropathy generally requires long-term treatment, the exact duration of which is uncertain. Typically, diabetic neuropathy is a chronic complication of diabetes and most often occurs around 8-10 years after diabetes. Diabetic neuropathy is a demyelinating lesion that can manifest as sensory-motor nerve damage, numbness, pain, and ankylosis in the extremities. Early sensory abnormalities, glove-like, late sensory loss and can be accompanied by atrophy of small muscle groups. It can also affect the function of gastrointestinal, cardiovascular, urinary system and sex organs, which can be manifested as delayed gastric emptying, diarrhea and constipation as well as abnormal sweating. Treatment of diabetic neuropathy includes strict control of blood glucose to prevent and delay the occurrence of diabetic neuropathy and prevent its further progress and deterioration. At the same time, attention should be paid to blood lipids, blood pressure and other standards, as well as control of smoking. Diabetic neuropathy treatment drugs need to be used under the guidance of a doctor, the specific treatment program should follow the doctor’s instructions.