Staying up all night with heart pain is a possibility of sudden death. If the patient is often tired, always stay up late, especially the weaker body, high blood pressure, diabetes, is possible to induce acute myocardial infarction leading to sudden death. Staying up all night will lead to dysfunction of sympathetic and vagal regulation, increase myocardial oxygen consumption, increase the incidence of coronary heart disease, and the risk of sudden death. If patients stay up late with cardiac discomfort, they should rest in a timely manner, if not relieved, you can try sublingual nitroglycerin and other drugs. If the symptoms are serious, then call 120 in time to clarify whether it is the occurrence of acute coronary syndrome. Stay up late heart pain may lead to sudden death, so usually must pay attention to the combination of work and rest, avoid staying up late, ensure sufficient sleep time.