Adenovirus infection in children can be difficult to cure completely. Children are more susceptible to infectious diseases because they are at a stage of weakened immune function. Adenovirus infections are prone to adenovirus pneumonia, which can also lead to comorbidities that can cause critical illnesses. There is no specific medicine for adenovirus, so it is difficult to cure adenovirus infection in children.1. Weak immune function: Children’s immune system is not fully developed and their immunity is weak, making them susceptible to adenovirus. At the same time, children’s ability to clear the virus on their own is weak, so the course of the disease may be longer than adults; 2, easy to lead to pneumonia: children infected with adenovirus will cause high fever persistently, coughing, breathing difficulties, will cause a large area of solid change in the lungs of children, easy to damage lung function, while the emergence of systemic symptoms of toxicity and other systemic dysfunction. The disease is more serious and has a higher mortality rate, and the disease is usually prolonged for several months; 3, easy to lead to comorbidities: infection with adenovirus can easily lead to urinary tract diseases, respiratory tract infections, as well as gastrointestinal tract, eye, lymph node infections, combined with other diseases also aggravate the difficulty of healing; 4, no special drugs: there is no special drug for the treatment of adenovirus, mainly symptomatic treatment, while protecting the function of various organs. Children infected with adenovirus should promptly seek medical attention, while parents should pay attention to children’s diet and living habits, eat more light and easily digestible food, avoid spicy and irritating food. Pay attention to hygiene, wash hands regularly, change clothes regularly, and drink water appropriately to improve the body’s metabolism and help the disease recover more quickly.