A diabetic foot with a blood blister needs to be treated by a doctor in a hospital and should not be treated by yourself. Treatment includes reducing activity, keeping local cleanliness and hygiene, surgical extraction of blood from the blisters if the blisters are large, and medication, including methylcobalamin, nerve nutrition, and hypoglycemic treatment. 1. Lifestyle intervention: diabetic foot blisters may be related to excessive friction, need to reduce activities, more rest, wear breathable cotton socks, soft shoes, maintain local hygiene, dietary light low-sugar diet, appropriate supplementation of high-quality protein. 2. Surgical treatment: for smaller blood blisters can be self-absorbed, can not be self-absorbed blood blisters or blood blisters larger, with the help of surgical means, the blood in the blood blisters extracted, is conducive to the absorption of blood blisters. 3. Drug therapy: diabetic foot is due to long-term poor glycemic control combined with peripheral neuropathy, vasculopathy, should be strict control of blood glucose, follow the doctor’s instructions to take glucose-lowering drugs on time, can be applied to methylcobalamin nutritional nerve. Diabetic foot patients with blood blisters are advised to go to the hospital in a timely manner, so that the professional doctor to deal with, do not do it yourself, because it is very easy to cause infection.