There are many diseases that lead to orofacial exudate, most of which are due to pathological changes in the mucosa of the mouth and lips, but the pathology of orofacial exudate caused by different diseases is different, so attention should be paid to differentiation when diagnosing, and attention should be paid to finding the cause while treating orofacial exudate, if orofacial herpes leads to orofacial exudate, small blisters usually appear first, while those caused by labyrinthitis usually appear first with inflammation and dryness of the lips. Herpes labialis leads to oral and lip oozing, which is characterized by burning, itching and flushing, followed by the appearance of dense clusters or several clusters of pinhead-sized blisters, which are smaller and more clustered than the primary blisters, rupture and erosion, oozing, and gradually drying and crusting, all in about 1 to 2 weeks, with temporary local pigmentation after healing.