Blackheads are also clinically known as blackheads and open pimples. Stubborn blackheads growing into the flesh can be treated by the following methods: 1, topical medication: you can choose to use topical retinoids, common ones such as retinoic acid cream, adapalene gel, etc.; you can also choose to use nonanedioic acid, common ones such as 20% azelaic acid cream; you can also choose to use topical anti-androgenic hormones, common ones such as androstadienone cream, etc.; you can also choose to use topical peroxymethylphenidate gel 2, systemic medication: you can choose to systematically use retinoids, common ones such as isotretinoin soft capsules, vitamin capsules. For physical therapy, fractional CO2 laser or acne squeezer can be used to squeeze out the acne contents. 3. Chemical peeling is also an option.