When the hepatitis B virus enters the body, the body’s defense system reacts to destroy the invading enemy, called the immune response. Since everyone’s “immunity” is different, the “outcome” of hepatitis B after entering the body is also different. Some can develop the disease, some do not; some and serious, some disease is light; some body can “win” the virus, the virus eliminated and resistance, some can not do anything about the virus, the virus replication, may develop into chronic hepatitis, cirrhosis, and even liver cancer. The “small three positives” refers to positive serum hepatitis B surface antigen (HBsAg), hepatitis B e antibody (anti-HBe), hepatitis B core antibody (anti-HBc). There are two types of “minor triple-positive”, one is that the serum is originally “major triple-positive” HBsAg, hepatitis B e antigen (HBeAg) and anti-HBc are positive, through the body’s immune response, HBeAg changed to anti-HBe, the examination When the serum is checked, it is “Little Three Positive”. If the liver function is normal, asymptomatic or with mild symptoms, it often means that viral replication has mostly stopped, liver inflammatory activity is quiescent, and infectiousness is low or absent. Another situation is due to the mutation of hepatitis B virus, although the serum test result is “small three positive”, but the hepatitis B virus replication in the body, the liver has a progressive chronic active inflammation, liver function abnormalities, or repeated fluctuations, easy to develop into severe hepatitis, cirrhosis or even liver cancer, so for “small three positive, especially with Therefore, the HBVDNA must be tested to determine whether the hepatitis B virus is replicating in the body, especially for those with abnormal liver function. In the first case, the patient does not need treatment, and the liver function and HBVDNA should be checked regularly, while in the second case, the patient needs to go to a regular hospital for consultation, treatment and follow-up, so as not to delay the disease.