Facial muscle spasm (also known as facial twitch) is an involuntary contraction of unilateral facial muscles caused by overexcitation of the facial nerve. According to statistics, the prevalence of this disease accounts for 6 per 10,000, and it was previously thought to have a high incidence in middle-aged women, but now studies have confirmed that the incidence is the same in men and women. The onset of the disease is characterized by occasional eyelid fluttering, which becomes more frequent and severe when emotionally excited (e.g., happy, angry, meeting someone you don’t know, etc.). Because of the superstition that “the left eye jumps for money and the right eye jumps for disaster,” many patients think that eyelid fluttering is a common occurrence and delay diagnosis and treatment. After the disease progresses, the eyelid jumping can gradually extend down to the corners of the mouth and facial twitching occurs. As the twitching becomes more severe, the duration of the twitching increases, and the interval is shortened, it affects the patient’s daily life, interferes with normal social life and work, and causes a serious psychological burden on the patient. The exact cause of the disease is unclear, and it is currently believed that vascular compression of the facial nerve roots is the main cause of facial spasms. Oral medication (e.g., antiepileptic drugs, sedative drugs, etc.) is ineffective and has many side effects. In some patients, microsurgery can be used to achieve a radical cure, but there are risks of facial paralysis, deafness, vestibular dysfunction, and the possibility of postoperative recurrence. In the early 1980s, Botulinum toxin type A was used in the clinical treatment of various neurological diseases in Europe and the United States. After more than 30 years of exploration and development, this method has been widely used in neurological diseases such as blepharospasm, spastic squint and dystonia. Facial muscle spasm is treated with botulinum toxin injections, which have few side effects and are effective for a longer period of time. Patients with recurrence can repeat the injection and still have satisfactory results. It does not affect normal work and life. Before botulinum toxin injection, intracranial and vascular diseases should be excluded, and cranial MRI and EEG should be performed.