The treatment of chronic bronchitis with emphysema is divided into stable and acute exacerbation treatment. Acute exacerbation period: (1) When there is severe wheezing, a large amount of nebulized inhalation treatment should be given, such as budesonide, ipratropium bromide inhalation, oxygen inhalation can improve the symptoms of chest tightness and shortness of breath, and maintain stable oxygen saturation. (2) Cough and phlegm: the main symptom of chronic bronchitis is cough and phlegm, and the cough and phlegm will be aggravated after combined infection, cough and phlegm medicines such as methenamine capsule and ambroxol can relieve the symptoms. (3) Antibiotics: most of the acute attacks of bronchitis combined with emphysema are triggered by infections, and at this time we need to use antibiotics empirically, such as piperacillin sulphadiazine, moxifloxacin needle, and improve the sputum culture, and according to the results of the drug sensitivity to adjust the antibiotics. 2. Stabilization period: (1) Appropriate rest, pay attention to warmth, drink more water, strictly prohibit smoking, while avoiding inhalation of dust and irritating gases. (2) Immune preparations can be applied to improve the body’s ability to resist disease and reduce attacks. (3) Surgery is needed when the diameter of pulmonary herpes reaches 1/3 of the chest cavity on one side, leading to compression symptoms. According to the severity of the disease, timely consultation, the need for individualized medication under the guidance of the doctor, pay attention to adverse reactions.