1, hypogonadotropic hypogonadism (IHH): including a large group of diseases, congenital GnRH neuron defects, pituitary gonadotropin deficiency or molecular structure abnormalities, pituitary hypothalamic tumors, chronic systemic diseases, mental stimulation, severe weight loss or long-term strenuous exercise can cause gonadotropin deficiency. If accompanied by hyposmia, it is called Kalman syndrome. The main objectives of treatment for men with IHH are: (1) to restore sexual function, improve libido, and enhance the quality and enjoyment of sexual life; (2) to promote and maintain the development of secondary sexual characteristics; (3) to increase bone density and prevent osteoporosis; (4) to improve adult growth hormone deficiency; (5) to reduce the risk of cardiovascular events; and (6) to restore fertility. Treatment is hormone replacement, including GnRH pulse pump therapy, gonadotropin therapy including chorionic gonadotropin (HCG) and urinary gonadotropin (HMG), which can promote the restoration of fertility. and sex hormone replacement, but only for the maintenance of secondary sexual characteristics and not for fertility. Among these treatments gonadotropin-releasing hormone pulse pump (GnRH pulse pump) replacement therapy is the most ideal and physiologically appropriate treatment for this disease. Turner syndrome is also known as congenital ovarian hypoplasia, which is characterized by short stature, webbed neck, and toddler-type female external genitalia with striped gonads and a chromosomal deficiency of X. Previously, this type of patient was called congenital gonadal hypoplasia. Turner syndrome can also be due to structural abnormalities of sex chromosomes, such as X chromosome with long arm isobaric Xi (Xq), short arm isobaric Xi (Xp) The clinical manifestations are related to the number of deletions, and those who are missing may still have residual follicles and may have menstruation, but amenorrhea may occur after a few years. The main goal of treatment is to promote height and restore normal female secondary sexual characteristics. This includes growth hormone to promote height and estrogen and progesterone artificial cycles. Stimulation of breast and genital development with estrogen is effective, but long-term use is required. Premature application of estrogen promotes early epiphyseal healing. Generally, height is promoted first, and then estrogen is used to make breast and genital development after the epiphysis has healed. Patients with Turner syndrome who have a uterus should be treated with estrogen and progestin cycle therapy, starting with small doses. Combined estrogen (Premarim) 0.3 mg/d is available or can be increased to 0.625 mg/d to induce breast development with little breakthrough bleeding. With estrogen cycle therapy, those with endometrium may have menstrual flow. The dose can be adjusted according to the patient’s response and is effective in small doses. It is generally not used before the age of 12 to prevent premature epiphyseal closure and is best used after the age of 15. Patients with Turner syndrome are detected and diagnosed early and treated early to solve her height problem before epiphyseal closure. After another decade, with the development of medical technology, there will certainly be more and more ways and means to solve their fertility problems. 3. Creutzfeldt-Jakob syndrome: The typical karyotype is 47,XXY, also known as congenital varicocele hypoplasia, which is a chromosomal abnormality disease. The incidence is 0.1%. Before puberty, there are usually no obvious symptoms. In adolescence, the symptoms are gradually obvious, the vulva is poorly developed, the penis is short, the testicles are small and hard, male secondary sexual development is delayed or even not developed, the skin is fine and white, the body hair is poorly developed, pubic hair and beard are scarce and axillary hair is often absent, the throat node is not obvious, the body is high, the lower body is longer than the upper body, and nearly half of the patients have gynecomastia breast development. Patients have low libido and poor sexual function, except for a few patients, almost all of them are azoospermic and cannot have children. At this stage of treatment, testosterone supplementation is given to promote masculinity, improve mental status, enhance sexual function, and thus improve the quality of life of the patients. In general, the treatment is still tricky. The fertility problem of patients with this disorder cannot be solved and only artificial insemination with donor semen can be used.