The sites of giant cell tumor of bone are as follows: 1) near the joints, especially near the knee joint; 2) proximal tibia and distal femur; 3) proximal humerus or distal radius; 4) other sites, including the spine and scapula, etc. In summary, giant cell tumor of bone can appear in the whole body skeleton, mostly in the knee joint, shoulder joint, wrist joint, etc. If there is pain in a certain area, X-ray can detect giant cell tumor of bone at an early stage, so that early treatment can be obtained with better results. Currently, many new drugs and various treatments have been developed in medicine, which can effectively relieve the disease and reduce the recurrence rate.