Colorectal cancer is one of the common malignant tumors in China. Although surgery is the main means to treat colorectal cancer, recurrence of bowel cancer after surgery is the key factor affecting the efficacy, and its recurrence rate after surgery is as high as 60%. Recurrent bowel cancer includes not only distant liver and lung metastases, but also local recurrence. Hepatopulmonary metastasis can still achieve better results through surgery, intervention and chemotherapy. Local recurrence includes peritoneal dissemination, invasion of adjacent organs such as pelvis and abdominal wall, kidney and uterine adnexa, bladder, prostate and seminal gland, etc., which is one of the difficulties in clinical treatment. The treatment of recurrent bowel cancer requires multidisciplinary joint diagnosis and treatment, mainly including general surgery, radiology, medical oncology, radiotherapy, pathology, urology, obstetrics and gynecology, bone oncology and so on. First of all, imaging plays an important role in the diagnosis of recurrent bowel cancer. CT, MRI and PET-CT can clarify the site, number, size, whether lymph nodes are metastatic or not, whether peritoneal metastasis is metastatic or not of recurrent bowel cancer. Through radiologists’ analysis of imaging, the next treatment plan can be decided. Secondly, patients with indications for surgery can be fully evaluated by general surgeons and undergo surgery if they are suitable for surgery. If recurrent bowel cancer invades the uterus and uterine adnexa, joint surgery by obstetricians and gynecologists is required. If the cancer invades the bladder, ureter, etc., the general surgeon and the urologist should perform surgery. Of course, if the bone is invaded, then general surgery combined with bone oncology is required to remove the invaded bone. The operation of recurrent bowel cancer is complicated and often requires joint surgery of two or even more departments. Once again, patients without surgical possibility need medical oncology or radiotherapy to provide treatment plan, including chemotherapy and radiotherapy. Chemotherapy is a systemic treatment, which is effective for bowel cancer and can control or even inhibit the growth of tumor cells. Radiotherapy, on the other hand, is a local treatment that can improve local symptoms such as pressure and invasion. Some patients can also obtain the possibility of surgery after radiotherapy and then undergo surgery. In addition, pathology can clarify the pathological nature of the lesion, which is the gold standard of clinical diagnosis. Moreover, genetic testing and immune index testing for patients play an important role in the selection of treatment plan and patient’s prognosis. In conclusion, the diagnosis and treatment of recurrent bowel cancer is one of the difficult clinical issues, which often requires joint evaluation by experts from multiple departments and the most appropriate individualized treatment plan for patients.