Blisters are usually not recommended to be picked if they are not particularly large, but the time of automatic remission cannot be determined and it needs to be clarified what is causing the blisters. There are many types of diseases that cause blisters, including blistering eczema, blistering-herpetiform ringworm, tinea pedis, herpes zoster, hand, foot and mouth disease, leukodystrophy, papular urticaria, and friction dermatitis. The time of automatic regression of blisters varies significantly from disease to disease. Some of these diseases have blisters that do not automatically subside without treatment, such as blistering ringworm and tinea pedis. Blisters from other causes take different amounts of time to disappear automatically, such as shingles, which generally takes 2-4 weeks to subside, and hand, foot and mouth disease, which generally takes about 1 week to subside. It is recommended to visit the dermatologic venereal disease department of the local hospital in time to clarify the type of disease under the guidance of the doctor and then treat it symptomatically without delaying too long to avoid aggravating the symptoms.