Too bad! Around the age of forty, this disease is nearly 100% cancerous! I don’t like to meet such patients because it’s too cruel! I’ve met several of them in the past few days. The most tragic one in my memory was the young man who had just finished his college entrance exams and his results were not yet available, but he already had a stomach full of cancerous metastases. Familial polyposis has the potential to become cancerous. As the name implies, multiple polyps grow inside the intestine, some densely covered. This disease is an autosomal dominant disease, and about 40% of offspring can develop it. It usually starts around the age of nine, and if left untreated, nearly 100% of cancer occurs around the age of forty. Among the precancerous diseases of colon cancer, familial polyposis has the highest chance of developing cancer. The main symptom of patients is blood in the stool. Sometimes it can be detected because of abnormal function of the intestine and intestinal loops, which are uncommon but should be noted. Foreign reports show that about two-thirds of patients with familial polyp have already had colon or rectal cancer by the time they are diagnosed. Familial polyposis is usually diagnosed at the age of thirty to forty years, and the lesions can become cancerous after ten to fifteen years of formation. Patients do not have symptoms of abdominal pain, blood in the stool and frequent abdominal pain, and symptoms such as abdominal pain, diarrhea and mucus and blood in the stool appear only when polyps appear more and larger. The average time from the appearance of symptoms to the definite diagnosis of intestinal polyps is about 10 years, while the average time from the appearance of symptoms to the malignant transformation of adenomatous polyps is about 15 years. Therefore, patients with familial polyposis generally have the highest rate of malignant transformation at the age of 40-45, and are prone to metastasis after malignant transformation and have a low 5-year survival rate after surgery. Familial polyposis is classified as an adenomatous polyp syndrome, in which multiple adenomas can be found throughout the colon and rectum. They range from the size of a soybean to several centimeters in diameter, and are often arranged in dense clusters, sometimes in bunches, with histology similar to that of a normal adenoma. Those with positive family history should be alerted to this disease, especially if there is mucus-purulent blood stool should be promptly seen in the hospital. If special pigmentation or hyperpigmentation of the lips and surrounding skin, oral mucosa and fingers are found, gastrointestinal imaging or fiberoptic gastroscopy and colonoscopy should be done promptly. If multiple polyps are found to be confined to the colon, surgical treatment is feasible; if the whole gastrointestinal polyp is found, close follow-up observation should be made; in case of haemorrhage, intestinal entrapment or intestinal polyp malignancy, resection of the diseased intestinal segment should be performed.