With the advancement of ophthalmic microsurgery technology cataract surgery is becoming more and more frequent. Post-cataract surgery endophthalmitis is a very destructive complication, once it occurs it has a great impact on the strength and has been given full attention in clinical practice, the incidence of post-cataract surgery endophthalmitis is about 0.042%-0.2%. 1. Data and methods: From 2003 to 2009, 12 patients (12 eyes) with endophthalmitis occurred after cataract IOL implantation in the hospital, including 8 male cases and 4 female cases, aged 29 to 77 years old, with an average of 66.37 years old. Eight cases were subacute endophthalmitis, two cases were acute endophthalmitis, and two cases were delayed endophthalmitis. All underwent triple incision vitrectomy with IOL removal, vitreous culture with drug sensitization, and intraocular injection and irrigation. Silicone oil injection was performed postoperatively in both cases. 2. Results: The postoperative inflammation was well controlled. Seven of the patients had visual acuity of 0.3 best visual acuity of 0.5 (58%), and three patients had no improvement in visual acuity with an immediate index, (25%). Two patients had no light perception of vision. (17% of cases). All patients retained their eyes. Microbiological examination of vitreous culture was positive in 9 cases (75% positive rate). 3. Discussion: Post-cataract surgery endophthalmitis often has fatal consequences for the patient’s vision, and because of its unacceptability, ophthalmologists are constantly working to reduce its incidence and minimize its harm. In a clinical study, the American Endophthalmitis Vitrectomy Study Group (endoph-than itisvitrectcm y study groin EV S [3]) reported that the main pathogens causing endophthalmitis originate from the patient’s eyelids and conjunctiva. The most common of these are G+ coccus infections, while bacilli and fungi are rare. It is generally believed that the pathogens of endophthalmitis are brought into the eye through penetrating surgical incisions, and it has been reported [4-5] that the positive rate of anterior chamber water cultures in cataract surgery averages at 20%. Obviously, the vast majority of these contaminations do not cause endophthalmitis, but are an important indicator to observe the effectiveness of prevention. a study by Thomas et al [6] showed that there is no critical step for the prevention of postoperative endophthalmitis, and only preoperative iodine payment disinfection has a role in prevention, while other reported preventive measures include preoperative eyelash clipping, saline flushing of the conjunctival sac, preoperative antibiotic spotting of the eye, intraoperative use of Other reported preventive measures, including preoperative eyelash clipping, saline irrigation of the conjunctival sac, preoperative antibiotic spotting, intraoperative irrigation with antibiotics, and postoperative subconjunctival injection, have had little success. The preventive effect of preoperative antibiotic spotting and intraoperative application of antibiotic-containing irrigation solutions has been controversial. There are many risk factors for postoperative cataract endophthalmitis, including age, systemic disease, ocular disease, corticosteroid use, surgical approach, incision date location, capsule integrity, implant material, and incision healing, among others. In several studies [5-8] showed that intraoperative posterior capsular membrane rupture is one of the important risk factors for postoperative endophthalmitis. The form and closure of the surgical incision is an important factor in preventing postoperative endophthalmitis [9]. Sherwoocl et al [10] noted that fluorescein applied to the bulbar conjunctiva during extracapsular surgery was seen to enter the anterior chamber with intraocular irrigation fluid along the aspiration tube and incision, speculating that the fundamentally different structure of the incision day may be an important factor in preventing bacterial entry into the anterior chamber, and used a x2 test to confirm that 5-7 mm incisions were more effective than Oshima [11] and Koch [12] reported that both temporal clear corneal incisions and self-closing superior scleral tunnel incision days provided satisfactory clinical results. The advantages of the clear keratotomy over some other techniques are the reduction of the near-operative time and the elimination of the conjunctival incision scar, but there is also the risk of intraoperative incision disruption, postoperative wound instability, corneal endothelial cell loss, and infection. In contrast, the tunnel design creates a self-closing flap, thus preventing the possibility of anterior chamber disappearance and subsequent entry of peripheral perfusate, and is therefore thought to improve intraoperative safety and reduce postoperative infections and complications. Vitrectomy combined with vitreous injection [3] is now recognized as an effective method for managing post-cataract endophthalmitis. Once diagnosed, post-cataract IOL endophthalmitis is treated as an ophthalmic emergency and vitrectomy is performed immediately to remove the infecting pathogens and their toxins, remove the exudate spots and send them for examination (improving the positive rate of microbiological examination and reducing the incidence of postoperative retinal detachment by traction). Our study concluded that treatment of endophthalmitis after cataract IOL implantation, once diagnosed, should include immediate vitrectomy and removal of the IOL, vitreous cavity injection and irrigation, and intraocular injection of silicone oil, and intraocular injection of silicone oil, which isolates the transmission route of intraocular bacteria. Our group of patients achieved good results with our treatment. 100% of the patients preserved their eyes. 58% of the patients achieved visual acuity of 0.3 or more. Therefore, we believe that endophthalmitis after cataract IOL should be performed as soon as possible with vitrectomy and intraocular injection of silicone oil.