Cirrhosis requires systemic treatment including general therapy, etiologic therapy, anti-fibrotic, anti-inflammatory, antioxidant and hepatoprotective therapy and treatment for complications. General treatment: Adequate rest and proper diet are essential for the regeneration and recovery of liver cells. Etiological treatment: for example, alcoholic cirrhosis must abstain from alcohol, hepatitis B and C cirrhosis require antiviral therapy according to the condition, and copper detoxification therapy is feasible for hepatomegaly. Anti-fibrotic treatment: In hepatitis B cirrhosis, fibrosis and even cirrhosis are reduced from liver histopathology after antiviral treatment with IFN-a or nucleoside (acid) analogues. Therefore, antiviral therapy is the basis of antifibrotic therapy. Several anti-fibrotic TCM formulations have shown some efficacy in experimental and clinical studies, but further large-sample, randomized, double-blind clinical trials with emphasis on liver histological findings are needed to further validate their efficacy. Anti-inflammatory, antioxidant and hepatoprotective therapies: glycyrrhetinic acid preparations, reduced glutathione, s-adenosylmethionine, silymarin preparations, polyunsaturated lecithin preparations and bicyclic alcohols have different degrees of anti-inflammatory, antioxidant and hepatocyte membrane and organelle protection effects, and their clinical application can improve liver biochemical indicators .