(Disclaimer: This article is for general science purposes only. To protect patient privacy, relevant information in the following content has been processed) Abstract: A 40-year-old male patient was admitted to the hospital with sore throat and malaise after exertion, which was not treated with special medication. 2 days ago the patient presented with fever temperature of 39°C and chills, and was seen in the fever clinic on the same day. After admission to the hospital, the examination was completed and the pathogenic NGS return was diagnosed as influenza B virus and Staphylococcus aureus, and was diagnosed as influenza B combined with severe pneumonia. After using pharmacological antiviral treatment, high-flow oxygenation and closed chest drainage, the patient’s body temperature dropped and his condition control improved. [Basic information] Male, 40 years old [Disease type] Influenza B combined with severe pneumonia [Hospital] The Second Hospital of Harbin Medical University [Date of consultation] January 2022 [Treatment plan] Drug therapy (Oseltamivir phosphate capsule + cefoperazone sodium sulbactam sodium for injection + moxifloxacin hydrochloride tablets + intravenous human immunoglobulin + cefazolin sodium for injection + vancomycin hydrochloride for injection) + high The patient was admitted to the hospital with sore throat for 4 days, aggravated with fever for 2 days, sore throat and weakness due to exertion 6 days ago, fever appeared 2 days ago, no temperature was taken, with cough, general muscle pain, no obvious cough, no respiratory distress, no abdominal pain, no abdominal distress, no abdominal pain, no abdominal distress, One day ago, the patient was still febrile and was seen at our fever clinic, and the laboratory results showed that the total white blood cell count was 2.26×10^9/L, total neutrophil count was 1.68×10^9/L, lymphocyte count was 10.9%, monocyte count was 14.2%, and eosinophil count was 14.2%. The chest CT showed multiple ground glass and patchy shadows in both lungs, with exudative shadows and solid changes along the bronchi. After admission, he was given oral anti-influenza virus with oseltamivir phosphate capsule, anti-infection treatment with cefoperazone sodium sulbactam and moxifloxacin hydrochloride tablets for injection, human immunoglobulin by sedation, oxygen by mask to 5L/min, finger oxygen about 85-89%, changed to oxygen by high flow through the nose, oxygen flow 45L/min, oxygen concentration 100%, finger pulse oxygen fluctuation at 95%-99%, and the patient’s mental status improved slightly. However, fever was still present in 2 days of treatment, so the patient was changed to continue to use oseltamivir phosphate capsule for antiviral, and was given cefazolin sodium for injection and vancomycin hydrochloride for injection for anti-infection according to experience. 3 days later, NGS of alveolar lavage fluid returned: influenza B virus and Staphylococcus aureus, and the diagnosis was influenza B combined with severe pneumonia. 4 days later, blood culture returned: Staphylococcus aureus, and cefazolin sodium for injection was discontinued, and the patient was continued to receive cefazolin sodium for injection and vancomycin phosphate. Oseltamivir capsule orally and vancomycin hydrochloride for injection quietly, after 5 days of treatment, the body temperature decreased to 38℃, but the temperature no longer decreased, consider the possible combination of Staphylococcus aureus and abscess chest, review the lung CT, according to the imaging, give closed drainage of the chest cavity, and chest flushing treatment for 1 week, the patient’s body temperature gradually decreased to 37.5℃, continue to consolidate treatment after 5 days, the body temperature decreased to 37.2℃. The patient was a severe pneumonia with influenza B combined with Staphylococcus aureus infection. The disease was characterized by rapid progression and the pathogenetic return confirmed the presumed pathogenesis, and maintenance treatment was continued. As recovery from cavitary lesions due to S. aureus pneumonia takes a long time, the patient was hospitalized for a total of 20 days with complete control of symptoms and significant absorption of lung images, and the patient was instructed to come back to the hospital for a review in 1 month. The patient needs to pay attention to the following points: 1. avoid straining, pay attention to warmth, this patient is due to stay up for a month, resulting in a decline in immunity caused by the flu; 2. fall and winter flu vaccination; 3. diet regulation, diet, in addition to quit smoking and alcohol, supplemented with a high protein diet; 4. increase resistance, appropriate for Daily life exercise, winter and spring climate change is faster, pay attention to open windows, keep indoor air circulation. V. Personal insight Influenza is very common in clinical practice, is an acute respiratory disease caused by influenza A, B, C 3 viruses respectively, influenza is common in winter and spring, the clinical manifestations of high fever, fatigue, headache, cough, generalized muscle aches and pains and other symptoms of systemic toxicity, while the respiratory symptoms are light. Influenza viruses are prone to mutation, highly contagious, generally susceptible to the population, and have a high incidence. Severe influenza and critically ill influenza are all pneumonia-type influenza. Pneumonia-type influenza starts with symptoms similar to typical influenza, but the disease rapidly worsens after 1-3 days, with high fever, cough, chest pain, and in severe cases, respiratory failure and multi-organ failure of the heart, liver, and kidneys (MODS), so once a high fever does not subside, it is important to seek prompt medical attention.