(Disclaimer: This article is for general use only. To protect patient privacy, the information in the following content has been processed.) Abstract: Myelitis can develop at any age, without gender differences. In this case, numbness and weakness of both lower limbs were diagnosed as transverse myelitis through physical examination and related tests, and the patient was given medication to relieve the symptoms of numbness and weakness of the limbs and the condition was stabilized. [Basic information] Male, 59 years old [Disease type] Transverse myelitis [Hospital] The Second Hospital of Harbin Medical University [Consultation time] February 2022 [Treatment plan] Drug treatment (injectable sodium methylprednisolone succinate, vitamin B1 tablets, methylcobalamin injection, monosialic acid tetrahexose ganglioside sodium injection, injectable ceftriaxone sodium) [Treatment cycle] Hospitalization for 9 days Effect of treatment] The symptoms of numbness and weakness of the limbs were relieved and the condition was stable. The symptoms included fever, headache, dizziness, nausea, vomiting, convulsions, etc. He underwent MRI at a local hospital, which showed abnormal signals in the t2-t12 spinal cord. The patient was admitted to our outpatient clinic. The patient showed symptoms such as poor sleep, loss of appetite and urinary and fecal disorders due to anxiety, and was advised to review the whole spinal cord MRI to observe the lesion changes and perform lumbar puncture. The patient was admitted to the hospital with normal cardiopulmonary examination, abdominal tenderness, and no pressure pain or rebound pain. Specialized physical examination showed that the patient was clear, speech was clear, bilateral pupils were round, light reflexes were present, left and right eye movements were still possible, there was no facial palsy, tongue extension was centered, neck strength was strong(-), proximal muscle strength of bilateral lower limbs was grade 2, distal muscle strength was grade 3, muscle tone of limbs was(-), tendon reflexes were present, deep and superficial sensation below the 10th plane of the chest was hypoesthesia, and pathological reflexes were negative. Full spinal cord MRI showed a slightly long T2 signal in the thoracic medulla, and transverse myelitis was considered. The lumbar puncture examination showed: cerebrospinal fluid sugar: 2.38 mmol/L; cerebrospinal fluid chloride: 110.0 mmol/L; cerebrospinal fluid pressure: 110 mmH2O; cerebrospinal fluid albumin: 299 mg/L; cerebrospinal fluid cell count: 3. The patient needed to use vitamin B1 tablets orally, methylcobalamin injection, sodium tetrahexose monosialate ganglioside injection intravenously due to nerve injury Nerve nutrition, also use injectable methylprednisolone sodium succinate high-dose shock treatment, and then gradually reduce the amount of treatment, give injectable ceftriaxone sodium anti-infection. At the same time, the patient was advised to relax and divert attention, and the patient’s family was told to communicate more with the patient, and the family cooperated, and the patient’s compliance was good. (Spinal cord MRI results) III. Treatment effect Through drug treatment, the patient’s limb numbness and weakness were relieved significantly during the 9-day treatment cycle. At the time of discharge, the patient had grade 4 muscle strength of both lower limbs, fluent speech, and the patient was in a better mental state than before. The hormone was gradually changed from static dosing to oral dosing, and the dose was slowly and gradually reduced. At the same time, hormone adjuvant medication was given to correct low potassium, low calcium and gastric mucosal damage, and the patient was instructed to follow up regularly in the outpatient clinic after discharge, and a follow-up visit was required once a month if the condition did not fluctuate significantly. As the attending physician, I can hardly express my happiness to see that the patient’s symptoms were improving day by day, and there was no problem to resume self-care. After the patient is discharged from the hospital, he needs to pay attention to the diet, strengthen nutrition, give easily digestible food, vitamin-rich food, such as fresh fruits and vegetables, to supplement multivitamins. Appropriate calcium supplementation is given to prevent bone decalcification. Patients with high spinal corditis or swallowing difficulties can be placed under a gastric tube. After discharge, the patient can apply some herbal aids under the guidance of the doctor to clear heat and detoxify, activate blood circulation, such as Banlangen, Yinhua and Dilong. If in aggravation, patients with sudden respiratory distress should promptly inform the doctor, or promptly follow up with the hospital. V. Personal insight The treatment of this disease includes medication, such as the application of corticosteroids, immunoglobulins, and nerve-nourishing drugs. It is also necessary to prevent complications, such as prevention of pneumonia, prevention of pressure sores, urinary and stool care, respiratory management, and ensuring nutrition. Finally, patients also need rehabilitation treatment, which should be started as early as possible for patients with stable disease to further promote the recovery of limb function. The disease has a rapid onset and patients should seek immediate medical attention if they develop uncomfortable symptoms to avoid serious consequences due to untimely treatment.