Diabetes mellitus postprandial blood glucose 18.6mmol/L can be treated with oral medications such as glibenclamide, repaglinide, metformin, acarbose, etc., and insulin injections if necessary under the supervision of a doctor. Oral hypoglycemic drugs include sulfonylureas such as glibenclamide, glinides such as repaglinide, biguanides such as metformin, α-glucosidase inhibitors such as acarbose, and dipeptidyl peptidase IV inhibitors such as selegiline, etc. All of the above medications should be used under the supervision of a doctor. It should be noted that there are individual differences in the effectiveness of drug use, and when oral hypoglycemic drugs are not effective in controlling blood glucose, combined injection of insulin may be needed for treatment. In addition to medication, it is also necessary to pay attention to diet control and appropriate exercise. Diabetes mellitus postprandial blood glucose 18.6mmol / L should consult a professional physician for diagnosis and treatment, so as to avoid delaying the condition.