There is no “diabetic leg pain from amputation” this statement, amputation is only one of the treatments for diabetic foot, but diabetic leg pain may also be diabetic peripheral neuropathy, diabetic lower extremity vasculopathy and other factors caused by different diseases have different treatments, such as medication, surgery and so on. 1. Diabetic peripheral neuropathy: there may be lower limb pain, sensory abnormalities and other symptoms, can follow the doctor’s instructions to use lipoic acid antioxidant treatment, Epalrestat to improve metabolic disorders, methylcobalamin nutritional nerve therapy. 2. Diabetic lower limb vasculopathy: atorvastatin can be used for anti-atherosclerosis treatment, and stent implantation and revascularization can be considered when accompanied by arterial occlusion. 3. Diabetic foot: there may be foot pain, hypothermia and other symptoms; lower limb ischemia can be treated with antiplatelet therapy, such as clopidogrel, etc., and cilostazol can be used to expand the blood vessels; surgical treatment includes vascular bypass surgery, amputation, etc., and amputation is only used in the case of severe gangrene, necrosis of limbs, or accompanied by the spread of infection. Diabetic patients with leg pain symptoms should go to the hospital in time, under the guidance of the doctor to clarify the cause and treatment.