Thyrotropin is an endocrine hormone secreted by pituitary tumors, and its value usually varies depending on whether the pituitary gland is normal or whether there is a thyroid disorder. If thyroid stimulating hormone levels are high, it is usually due to abnormal secretion from the pituitary gland or a thyroid disorder. For example, primary hypothyroidism, thyrotropin-secreting pituitary tumors, hypopituitarism, hypothyroidism, and subacute thyroiditis can cause high thyroid stimulating hormone levels. If the thyroid gland does not produce enough thyroxine to meet the body’s needs, then thyroid stimulating hormone secretion will increase, which is a sign of hypothyroidism and the main cause of elevated thyroid stimulating hormone. Some diseases such as primary hypothyroidism, hypothyroidism, and subacute thyroiditis can affect the normal function of the thyroid gland to secrete thyroxine, causing an increase in the secretion of thyroid stimulating hormone, which can lead to a high level of thyroid stimulating hormone when blood is drawn for thyroid function tests. Another cause is abnormalities in the pituitary gland that secretes thyroid hormone, such as thyrotropin-secreting pituitary tumors and hypopituitarism, which can cause lesions in the pituitary gland itself, leading to abnormal secretion of thyroid stimulating hormone and high thyroid hormone levels. If a blood test reveals elevated thyroid stimulating hormone levels, further tests must be done to identify the specific cause and then treat it in a timely manner, otherwise it will be very detrimental to your health.