Inflammatory bowel disease (commonly known as ulcerative colitis, Crohn’s disease, etc.) is a very difficult group of diseases frequently encountered by anorectal and gastroenterologists. The diagnosis of this disease is easily determined by the patient’s symptoms, the physician’s examination, and relevant tests such as electronic colonoscopy and pathological biopsy. However, the treatment is very difficult, and one of the typical characteristics of the disease is that the symptoms are easily recurring. Patients often suffer from severe blood in the stool, mucopurulent stools and lingering abdominal pain, which seriously affect their physical and psychological health. In my long-term clinical practice, I often see such patients referred from major hospitals around the world. Generally speaking, these patients have been on regular Western medical treatment for a long time, and almost all of them have a long history of heavy hormone use. However, the symptoms of colitis still recur frequently, and many patients are in despair. By summing up the clinical experience, I propose that the treatment of inflammatory bowel disease must focus on “six combinations”: combination of Chinese and Western medicine, combination of internal and external treatment, combination of pharmacological and non-pharmacological treatment, combination of conservative treatment and surgical treatment, combination of somatic treatment and psychological treatment; combination of inpatient treatment and out-of-hospital conditioning.