Diabetic leg pain may be caused by diabetic peripheral neuropathy, diabetic peripheral vasculopathy, lower extremity skin infections and other disease factors, need to be under the guidance of the doctor to carry out targeted treatment, such as medication, surgery and so on. 1. Diabetic peripheral neuropathy: when diabetic patients have poor blood sugar control, it will lead to peripheral neuropathy, such as pain, numbness, sensory abnormalities and other symptoms of the limbs. It is necessary to actively control blood glucose, but also can use lipoic acid anti-oxidative stress, pancreatic kininogenase to improve microcirculation, methylcobalamin nutritional nerve and so on. 2. Diabetic peripheral vasculopathy: When diabetic patients have peripheral vasculopathy, the blood supply to the lower limbs will be insufficient, and when it is serious, it can be very difficult to walk, and even intermittent claudication and calf pain. First of all, we need to actively control blood sugar, but also can use clopidogrel, aspirin antiplatelet, statin drugs to stabilize plaque, bezoprost to improve microcirculation, if necessary, stent implantation treatment. 3. Lower limb skin infection: diabetic patients with lower limb ulceration, if poor glycemic control and accompanied by diabetic neuropathy and vasculopathy, it is easy to skin infection, ulceration and tissue destruction, which will cause pain. The first step is to actively control blood sugar, anti-infection treatment, improve local microcirculation treatment, surgical treatment. Diabetic patients with leg pain should go to the hospital and ask the doctor to clarify the cause of the disease and give treatment measures.