Facial myasthenia and Meijer’s syndrome have similarities in terms of patient presentation, but in fact they are two different diseases that many people tend to confuse. The difference is that facial myasthenia is a unilateral eye blink accompanied by involuntary twitching of the corners of the mouth on the same side, which is more affected by emotions and more frequent when emotional and communicating with others. In contrast, Major’s syndrome is characterized by simultaneous bilateral eye and mouth-lip twitching without obvious intervals, which can be stopped when singing or whistling. Facial myoclonus is a paroxysmal involuntary twitching of the hemifacial muscles, usually limited to one side of the face, hence the name hemifacial spasm, occasionally seen on both sides. The majority of patients with primary facial spasms develop after middle age, with more women. The twitching of the corners of the mouth is the most noticeable, and in severe cases, it may even involve the ipsilateral broad neck muscles, but the frontal muscles are less frequently involved. Major’s syndrome is an adult-onset dystonic disorder of the face. Symptoms usually occur in the 50s or 60s and are characterized by eyelid spasms, non-random movements of the lower face, jaw and neck. As symptoms progress, spastic dysphonia, dystonia of the neck, trunk, and extremities, and difficulty eating and swallowing may occur. Patients with Meijer syndrome may experience dramatic reduction in symptoms when yawning, eating, coughing, etc. Major’s syndrome can lead to disability, impairing the patient’s ability to read, drive a motor vehicle, or write, and in the most severe cases, can lead to functional blindness. Therefore, patients with Meijer’s syndrome should not engage in relatively dangerous work. If facial spasm is not treated in time, it will cause patients to be restless, irritable, irritable, insomnia, and in serious cases, facial muscle atrophy, which will show that one side of the patient’s face is big and the other side is small, seriously affecting normal life, work and study, and making patients less confident in normal life. After facial muscle spasm, patients will become reluctant to interact with others, and their character will become more and more inferior, and they will make their own way and make their own mistakes. Some patients often show fatigue, nervous depression, depressed mood, and even have no interest in anything, becoming depressed and losing confidence in life.