Facial myoclonus and Meijer’s syndrome have similarities in terms of symptoms, so many patients confuse these two diseases, which affects the treatment. Our hospital has seen many such patients and has accumulated some experience in the correct diagnosis of both diseases. The following is a detailed explanation of how facial myoclonus differs from Meijer’s syndrome. One: The symptoms and signs of the two diseases are different. Both diseases show frequent involuntary blinking, but the difference is that facial myoclonus is unilateral eye blinking, accompanied by involuntary twitching at the corners of the same side of the mouth, which is more affected by emotions, and twitching is more frequent when emotionally excited and when communicating with others. In contrast, Major’s syndrome is characterized by simultaneous bilateral eye and mouth-lip twitching, with no obvious interval, which can be stopped when singing or whistling. Secondly, the causes of the two diseases are different. Facial myoclonus is due to the compression of the facial nerve root by intracranial blood vessels, and the throbbing of the blood vessels stimulates the facial nerve and causes eye and facial twitching, which is a congenital carry-over with an acquired onset, and the compression of the facial nerve root is the main cause and the root of the disease. In contrast, Meijer’s syndrome is a psychological disease, most of the patients with this disease are introverted, withdrawn, love to be more serious and good at drilling, and all the tests are not abnormal. The cause of facial myoclonus is the compression of the facial nerve by intracranial blood vessels, which causes facial and eye twitching. The treatment of Meijer’s syndrome, which is also a psychological disease, is completely different from that of facial myospasm. While doing a good job of treatment, patients should be given psychological guidance, encouraged to establish confidence in overcoming the disease, strengthen physical exercise, communicate more with people, and participate in more group activities, especially recreational activities. Patients with facial myasthenia can fundamentally solve the problem of compression by using microvascular decompression. Patients with Meijer’s syndrome, on the other hand, need to be treated with brain pacemaker surgery. Most patients with Meijer’s syndrome in our hospital can significantly improve after a period of aggressive and comprehensive treatment. Microvascular decompression: Under general anesthesia, a 100px longitudinal incision is made behind the affected ear and in the hairline, and a cranial hole, approximately 50px in diameter, is made to access the pontocerebellar angle under the microscope. Once the responsible vessels are isolated, the source of irritation disappears, and the hyperexcitability of the trigeminal nucleus disappears and returns to normal. In the vast majority of patients, the pain disappears immediately after surgery, and normal facial sensation and function are preserved without affecting the quality of life. Pacemaker surgery: Under local + general anesthesia, a coin-sized hole is drilled 1-2 centimeters behind the bun, and a needle-tip electrode is inserted deep into the nucleus that controls the symptoms, before being connected to the subcutaneous buried battery in the chest through an extension wire via a subcutaneous tunnel. The battery of a brain pacemaker system typically lasts 5 to 10 years, and if the battery is depleted, the pulse generator needs to be replaced; the electrodes and leads do not need to be replaced. This can be replaced with a simple surgical procedure.