Pediatric erythroleukemia is a disease that often occurs in infants and young children, we do not want our children to be troubled by pediatric erythroleukemia, so many parents want to understand the causes of pediatric erythroleukemia, we all know that the causes of the disease is essential for us to prevent and treat the disease, so the following is a detailed introduction to the causes of pediatric erythroleukemia for parents and friends. I, the cause of the pathogenesis is unknown so far, some people believe that a subtype of acute granulocytic leukemia, which manifests itself as a malignant hyperplasia of the red, white (mainly granular) two lines, and finally can develop into a typical acute granulocytic leukemia, the development process is: red blood → red leukemia → leukemia, but not every case has such a transformation process, some cases may die before the transformation, and thus Although the erythroleukemia caused by Friend virus is very similar to this disease, the relevant virus that causes the disease in humans has not been isolated. The pathogenesis of true red clonal hematopoietic stem cell disease is still unclear, and the excessive production of erythrocytes in the blood is not due to a particularly long life span of erythrocytes. Studies of the relationship between EPO and true erythrocytosis have shown that in most patients the level of EPO in plasma and urine not only does not increase but is significantly reduced or even undetectable, contrary to secondary erythrocytosis, and recent in vitro cell culture studies have shown that there may be 2 groups of erythroid stem cells in the bone marrow of true red, one group being an abnormal cell line that proliferates faster than normal, even in the absence of EPO When the abnormal cell line produces a large number of erythrocytes, the secretion of EPO is inhibited, and the normal cell line is in a relatively dormant state. In vitro cultures have shown that the bone marrow of patients with true red can produce erythrocyte colonies without the addition of EPO, and there are two explanations for this situation. The pathogenesis may not be in the EpoR link, and other studies RT-SSEP and DNA-SSEP analysis of EpoR-DNA and EpoR starting small regions, respectively, did not find point mutations, and sequencing of the entire PCR product encoding the EPO gene region did not reveal any abnormalities, further confirming the absence of abnormalities in the EpoR gene in true red. For pediatric erythroleukemia many small children have suffered, but the danger of this disease is more clear to us as parents, their children are plagued by the disease is how unbearable, in order to keep their children away from the disease, as parents to understand these diseases, only a thorough understanding of the causes of pediatric erythroleukemia, in order to better protect their children from pediatric erythroleukemia.